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Purpose The aim of this study was to evaluate the clinical, histological, hematological, and oxidative stress effects of cannabidiol (CBD) in mice with induced oral mucositis. Methods We used 90 mice of the CF‐1 strain in which oral mucositis was induced using a protocol with 5‐fluorouracil (5‐FU) chemotherapy. The animals were divided randomly into 10 study groups. Three groups were treated with different doses of CBD (3, 10, and 30 mg/kg), while 2 were control groups (positive control: 5‐FU + mechanical trauma + placebo; and negative control: mechanical trauma + placebo), and 2 experimental times were studied (4 and 7 days). All treatments were by intraperitoneal administration. Results In the clinical evaluation, the groups treated with CBD showed less severity of oral lesions compared with the positive control at both experimental times. The intensity of the inflammatory response was also lower in the groups treated with this drug, but there was no statistically significant difference when compared with the positive control. With regard to erythrocyte, leukocyte, and platelet counts and anti‐oxidant enzyme activity, the groups treated with CBD showed better results, but only some of these variables showed statistically significant differences. Conclusions CBD seems to exert an anti‐inflammatory and anti‐oxidant activity favoring a faster resolution of oral mucositis in this animal model.

Use of polymethylmethacrylate as permanent filling agent in the jaw, mouth and face regionsimplications for dental practiceObjectives: This article is a review of PMMA focusing on its properties, indications, contra-indications and adverse effects. Background: The search to remain young is a constant attitude among Brazilians. The low cost of filling agents have stimulated its indiscriminate use, especially the bioplasty (non-incisional method). Polymethylmethacrylate (PMMA) is the cosmetic filling agent of choice, because of its low cost, easy access and simple application technique. The impact on dentistry and orofacial medicine needs further awareness. Conclusion: The article aims to draw the attention of odontology and medical professionals to the product's applicability and its possible complications.

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