Multiple lymphomatous polyposis (MLP) is a rare condition, described in the literature as a presentation of extranodal mantle cell lymphoma. We report a rare case of follicular lymphoma presenting as MLP in a young woman with a short history of haematochezia who underwent colonoscopy. Immunohistochemistry on colonic biopsies confirmed follicular lymphoma. Microscopic examination found an extensive and dense lymphoid infiltrate, which demonstrated a follicular growth pattern. The neoplastic cells were positive with BCL2, BCL6, CD10 and CD20, and were negative with CD3, CD5, Cyclin D1 and SOX11. CT staging showed disseminated lymphadenopathy and the patient was commenced on chemotherapy. Endoscopic evaluation and histopathological analysis are vital for the accurate diagnosis of MLP. Our case demonstrates that follicular lymphoma should be considered as a differential, as not all cases of diffuse colonic MLP are related to mantle cell lymphoma. This distinction must be made to provide the best clinical management for the patient.
Plasma cell granuloma (PCG) is a mucosal condition characterised histologically by a dense aggregation of polyclonal plasma cells. There are limited reports in the literature of the condition affecting the oral mucosa and involvement of the gingival tissues is considered rare. The variable clinical presentation allows for a differential diagnosis of malignant conditions therefore awareness of the characteristics and distinctive histological features are important in avoiding misdiagnosis. We report a rare case of PCG presenting on the buccal gingivae of the posterior mandible, with concurrent mobility of the adjacent tooth, in a middle‐aged female. The clinical presentation of this lesion warranted urgent investigation, however, histological findings of a dense polyclonal plasma cell infiltrate revealed a benign PCG.
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