Nanocomposite hydrogels or nanogels (a nanoparticles composed of a hydrogel) are nanomaterial filled, swollen nanosized networks of deliquescent or amphiphilic compound chains. It may be developed by drug - polymer interactions and to create 3D advanced networks. Nanogel may be ready by many strategies just like the particle gelation, Inverse mini emulsion, Dispersion, Chemical cross linking, fabrication of biopolymers and so on. It can be characterized by SEM, DSC, FTIR, Drug content, Particle size, Zeta potential and drug efficiency.  Further, it can be evaluated by in vitro drug release and in vivo study in suitable animal modeling. In this review article, we have focused on basic methodology of nanogels, evaluation terms, their application in industry with future prospects for the researchers. Keywords: Nanogel; methods of nanogel preparation; evaluation parameters and their applications.

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Objectives: The current study work was aimed to improve the solubility of Apixaban by forming co-crystals. Materials and Methods: Two solvents mainly Dimethyl Sulphoxide (DMSO) and 2,2,2-trifluoroethanol were tried during the formulation of co-crystals. The other chemicals oxalic acid, adipic acid and L-Tartaric acid were used. Results: From the different trials it was concluded that oxalic acid and DMSO combination with the drug gave the better results for improvement in the solubility. Hence the batch F3 was analysed further. The melting point of F3 was found lower than pure drug. Drug content was found optimum as 95.06 ±0.65%. FTIR-spectra demonstrated the combined peaks of drug and oxalic acid. DSC thermogram showed the sharp endothermic peak similar to pure drug. SEM and XRD spectra confirmed the formation of co-crystals. Conclusion: It was found that formation of co-crystals of apixaban and oxalic acid was satisfactory and it was beneficial to improve the solubility of the apixaban.