Background:Āmalaki (Embelica officinalis Gaertn.) is one of the most celebrated herbs in the Indian system of traditional medicine. It is one of the best Rasāyana-s (health promoting) drug. In Dugdhāmalakyādi yoga, Āmalaki (Embelica officinalis Gaertn.) powder is administered along with milk in case of svarabhaṅga (hoarseness of voice). Here an attempt is made to convert this formulation into chewable tablet without altering its property to improve its palatability, shelf life and fixation of proper therapeutic dose.Methodology:Chewable tablets were prepared by wet granulation method. Here, Āmalaki powder was prepared initially and it was mixed with additives and preservatives. Granules were prepared from this mixture by adding binding agent, finally compressed in to tablets.Results and Conclusion:The physico-chemical analysis of Āmalaki standard are: Foreign Matter-Nil, Acid insoluble Ash-0.51%w/w, Water soluble Ash-2.01% w/w, Alcoholic Extractives-44.48%, Aqueous Extractives 67.52%, pH-3.1, Moisture content-8.19%. Quality control test for chewable tablet was carried out and found satisfactory with general characteristics of tablet viz. hardness 1.8, disintegration time 15-20 min, friability 0.5%, weight variation +/- 3%. The TLC of Āmalaki powder showed 3 spots with Rf value 0.14, 0.4, and 0.73 and the chewable tablets showed 2 spots with Rf value 0.31 and 0.89 under 254 nm. The adaptation of modern techniques or methods to convert the Ayurvedic formulations without altering its therapeutic property is necessary to made them suitable for the present trends of newer drug delivery dosage forms.

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Introduction: It has been estimated that in India, 65%, i.e., nearly 80 million children under 5 years of age suffer from varying degrees of malnutrition. Most of the children fall into the pit of Malnutrition during the weaning phase. Mothers are expected to make this “weaning Bridge.” This includes utilization of “Supplementary Feeding Programs.” Many weaning foods are available which claims the specific dietary implementation. The development of a nutritive Powder in weaning children is need of hour. This study includes safety of novel Ayurvedic nutritive powder in Wistar rat pups. Aim: This study aims to evaluate its safety in experimental animals. Materials and Methods: Ingredients selected were Mudga, Godhuma, Rakta Shali, Ragi, Trikatu, Yastimadhu, and Khanda Sharkara. Safety study of Nutritive Powder was done in 20 days old Wistar Rat pups for 90 days. Parameters selected are HISTOPATHOLOGICAL study and biochemical investigations. Results: No mortality and abnormal behavioral changes were found in rat pups during experimental study. No remarkable pathological changes were observed. Biochemical Parameters revealed significant decrease in blood sugar, serum urea, and alkaline phosphatase in test group when compared to control. Conclusion: Nutritive powder when administered in the dose of 40 g/Kg body weight of animal for 90 days. No mortality was seen in any animals of test group. No remarkable pathological changes were seen in histopathological study of liver and kidney. Significant decrease of blood glucose, serum urea serum alkaline phosphatase was seen in test group animals compared to control group animals.

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