ARK5 led to a more invasive phenotype and metastatic potential in human breast cancer dependent on Akt.

Abstract. Southwest China is located in the southeastern margin of the Tibetan Plateau and it is a region of high seismic activity. Historically, strong earthquakes that occurred here usually generated lots of landslides and brought destructive damages. This paper introduces several earthquaketriggered landslide events in this region and describes their characteristics. Also, the historical data of earthquakes with a magnitude of 7.0 or greater, having occurred in this region, is collected and the relationship between the affected area of landslides and earthquake magnitude is analysed. Based on the study, it can be concluded that strong earthquakes, steep topography as well as fragile geological environment, are the main reasons responsible for serious landslides in southwest China. At the same time, it is found that the relationship between the area affected by landslides and the earthquake magnitude in this region are consistent with what has been obtained worldwide. Moreover, in this paper, it is seen that the size of the areas affected by landslides change enormously even under the same earthquake magnitude in the study region. While at the same tectonic place or fault belt, areas affected by landslides presented similar outline and size. This means that local geological conditions and historical earthquake background have an important influence on landslides distribution, and they should be considered when assessing earthquake-triggered landslide hazards at Grade 1 according to ISSMGE.

Many offshore marine structures are built on seabeds with slight or considerable slopes, while most analytical studies have focused on the dynamic responses of horizontal seabeds. Based on the theory of porous media, an analytical solution for the response of a sloping seabed to earthquakes is developed in this paper. Stress and displacement responses can be shown at any location of the seabed.Using numerical examples, we analyze the influence of the slope angle, frequency and angle of incident waves, and thicknesses of the seawater and sediment layers on the dynamic response of the seabed. The results show that the solid displacement amplification factor of the surface of the horizontal seabed is always constant, while that of the sloping seabed changes periodically along the seabed surface. Even at a small site, the difference between a horizontal seabed and a sloping seabed is still significant. The slope angle has different effects on the seabed at different depths, and the inclination plays an amplification role at some depths and a reduction role at other depths. With an increase in slope angle, the difference between a horizontal seabed and a sloping seabed becomes more significant. Especially at natural frequencies, the amplification factor becomes more significant with increasing slope angle. Therefore, even though the same seawater depth is used in the model, a horizontal seabed model cannot be used to analyze the dynamic response of a sloping seabed or significant errors will occur.

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Immersed tunnels are typically built in areas subjected to ground motion. Therefore, an evaluation of the seismic performance of the soil-tunnel system is essential. A series of shaking-table tests was conducted to study the influences of the site soil and overlying water layer on the seismic responses of soil deposits and an immersed tunnel. Detailed information on the experiment setup is provided with special focus on the similitude relationship, fabrication of the model system, measurement setup, and loading procedures for a simulation of the seismic waves. Three groups of tests at different sites in dry sand, saturated sand, and saturated sand with an overlying water layer were carried out using the same seismic excitations. The seismic responses of the soil deposits and the dynamic responses of the tunnel model were obtained. The experiment results indicate that, when considering only horizontal earthquake excitations, soil liquefaction significantly influences the propagation of seismic waves and the dynamic responses of the tunnel, whereas the water layer has no obvious effects on the dynamic performance of the ground or tunnel. Furthermore, the acceleration responses of the tunnel elements were analyzed qualitatively, and the joints are deemed important elements in an antiseismic immersed tunnel design.