A series of novel pyrazole-4-carboxamide compounds were designed and synthesized through introducing a tertiary alcohol moiety into the C-3 position of the pyrazole ring based on the chracteristics of pyrazole-4-carboxamide fungicides and natural products with a tertiary alcohol moiety. Their structures were characterized by 1 H NMR, 13 C NMR, HR-ESI-MS data and X-ray diffraction. The preliminary bioassay results indicated that some of these compounds exhibit certain fungicidal activities against tested phytopathogens at the concentration of 100 µg/mL. N-(2-Fluorophenyl)-3-(1-hydroxycyclohexyl)-1,5dimethyl-1H-pyrazole-4-carboxamide (B 1) and N-(thiazol-2-yl)-3-(1-hydroxycyclohexyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide (B 10) have EC 50 values of 76.3 and 71.9 µg/mL against Pythium aphanidermatum. B 10 has an EC 50 value of 85.4 µg/mL against Phytophthora capsici, respectively.

Benzyl chloride and its derivatives are important intermediates, the benzyl-type chlorinated hydrocarbons tend to have reaction with kinds of nucleophilic reagents, such as OH -, OR -, CN -, NH3, etc., give new functional groups. This review summarizes these reactions and makes discussions according to introduce different groups and compares different kinds of reactions.