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Nanomaterials at the neural interface can provide the bridge between bioelectronic devices and native neural tissues and achieve bidirectional transmission of signals with our brain. Photoactive nanomaterials, such as inorganic and polymeric nanoparticles, nanotubes, nanowires, nanorods, nanosheets or related, are being explored to mimic, modulate, control, or even substitute the functions of neural cells or tissues. They show great promise in next generation technologies for the neural interface with excellent spatial and temporal accuracy. In this review, we highlight the discovery and understanding of these nanomaterials in precise control of an individual neuron, biomimetic retinal prosthetics for vision restoration, repair or regeneration of central or peripheral neural tissues, and wireless deep brain stimulation for treatment of movement or mental disorders. The most intriguing feature is that the photoactive materials fit within a minimally invasive and wireless strategy to trigger the flux of neurologically active molecules and thus influences the cell membrane potential or key signaling molecule related to gene expression. In particular, we focus on worthy pathways of photosignal transduction at the nanomaterial−neural interface and the behavior of the biological system. Finally, we describe the challenges on how to design photoactive nanomaterials specific to neurological disorders. There are also some open issues such as long-term interface stability and signal transduction efficiency to further explore for clinical practice.

We aim to test if a blazar candidate of uncertain-type (BCU) in the third Fermi active galactic nuclei catalog (3LAC) can be potentially classified as a BL Lac object or a flat spectrum radio quasar (FSRQ) by performing a statistical analysis of its broadband spectral properties. We find that 34% of the radioselected BCUs (583 BCUs) are BL Lac-like and 20% of them are FSRQ-like, which maybe within 90% level of confidence. Similarly, 77.3% of the X-ray selected BCUs (176 BCUs) are evaluated as BL Lac-like and 6.8% of them may be FSRQlike sources. And 88.7% of the BL Lac-like BCUs that have synchrotron peak frequencies available are high synchrotron peaked BL Lacs in the X-ray selected BCUs. The percentages are accordingly 62% and 7.3% in the sample of 124 optical-selected BCUs. The high ratio of source numbers of the BL Lac-like to the FSRQ-like BCUs in the X-ray and optically selected BCU samples is due to the selection effect. Examining the consistency between our evaluation and spectroscopic identification case by case with a sample of 78 radio-selected BCUs, it is found that the statistical analysis and its resulting classifications agree with the results of the optical follow-up spectroscopic observations. Our observation campaign for high-|ρ s | BCUs , i.e., |ρ s | > 0.8, selected with our method is ongoing.