Noninvasive electrophysiological signal monitoring is significant for health care and scientific research. The simultaneous achievement of wet adhesion, stretchability, breathability, and low contact impedance is highly recommended in the epidermal electrode but still challenging. In this work, a monolayer porous film electrode with a pore size and wall thickness of less than ∼10 μm is fabricated via the breath figure method (BFM) and metal sputtering, and it was subsequently applied using epidermal electrophysiological monitoring. The ultrahigh permeability is comparable to the naked skin because the through holes of the monolayer porous film match well with the pores on human skin. The stretchability of 50% is realized with the combination of Au microcrack and the monolayer porous structure. The wet adhesion of 0.17 N/cm is established on the chemical bonding between the electrode and the epidermis. The contact impedance is comparable with the gold standard Ag/AgCl gel electrode, especially after sweating. Stable and precise electrophysiological signals are measured. Especially, the perspiration resistance of the monolayer porous film outperforms that of the gel electrode. The monolayer porous structure provides a new avenue to improve the breathability of the epidermal electronics.

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The rapidly advancing improvements in perovskite solar cells (PSCs) are driven, in part, by the inclusion of suitable electron transport layers (ETLs) in high performance devices. Fullerene derivatives are particularly useful ETLs in PSCs, but many of the utilized fullerenes are present as isomeric mixtures. The opportunities presented by single‐isomer, single‐enantiomer fullerenes in PSCs are poorly understood. Here, inverted PSCs are prepared using bis[60]phenyl‐C61‐butyric acid methyl ester derivative (anti)16,17‐bis[60]PCBM, comparing the performance of enantiomerically pure material to the corresponding racemate. The single enantiomer devices are found to have an improved performance, giving a power conversion efficiency (PCE) of 23.2%, compared to 20.1% PCE for the racemate. It is also shown that enantiomerically pure PSC modules can be prepared with a state‐of‐the‐art PCE of 20.1%. Such excellent performance for the single enantiomer devices is accompanied by enhanced operational stability. This study thus provides strong evidence that single isomer ETLs can provide important improvements in PSC performance and it positions chiral fullerenes as an exciting material class moving forward.

a 郑州大学药学院 郑州 450001) (b 新药创制与药物安全性评价河南省协同创新中心 郑州 450001) (c 河南省药物质量评价重点实验室 郑州 450001) (d 教育部药物制备关键技术重点实验室 郑州 450001) 摘要 为了寻找高效的抗肿瘤药物, 设计并合成了一系列含苯并噻唑砌块的 2,4,6-三取代嘧啶衍生物. 采用噻唑蓝 (MTT)法对目标化合物在人类四种癌细胞[EC-109(人食管癌细胞)、MGC-803(人胃癌细胞)、PC-3(人前列腺癌细胞)、 HepG-2(人肝癌细胞)]、GES-1(人正常胃黏膜上皮细胞)和 HEEC(人正常食管细胞)中进行抗肿瘤活性评价, 结果显示部 分化合物对 MGC-803 和 PC-3 细胞表现出中度至强效的抗肿瘤活性. 其中 2-(((4-(4-(吡啶-2-基)哌嗪-1-基)-6-(三氟甲基) 嘧啶-2-基)硫基)甲基)苯并[d]噻唑(13h)和 2-(((4-(4-(嘧啶-2-基)哌嗪-1-基)-6-(三-氟甲基)嘧啶-2-基)硫代)甲基)苯并[d]噻 唑(13i)对 PC-3 表现出比较好的抗肿瘤活性, IC 50 值分别 3.82 和 2.29 μmol/L, 且化合物 13h 和 13i 对 GES-1 的细胞增值 毒性明显小于阳性对照 5-氟尿嘧啶.

Selective oxidation of sulphides to produce sulfoxides or sulphones is a key technique in industry. In this paper, we found that, the reaction could be catalyzed by the PhSe(O)OH/Al(NO3)3 system...