Leukocyte cell–derived chemotaxin 2 enhances phagocytosis and bacterial killing of macrophages to improve the outcome of bacterial-induced sepsis.

In the main drive system of a rolling mill, shaft torsional vibration is often generated when a motor and a roll are connected with a flexible shaft. State feedback control can effectively suppress the torsional vibration of the main drive system of a rolling mill. Because of the difficulty of measuring the load speed and the shaft torque, and moreover the sensitivity of the Luenberger observer to the model uncertainties and the noise include in the detected signal, in this paper, we propose an extended state observer (ESO), a new observer, to estimate the unknown states and the load torque disturbance. We propose an ESO and linear quadratic (LQ) based speed controller with an integrator and load torque feedforward compensation for torsional vibration suppression in a two-mass main drive system of a rolling mill. The simulation results show the controller effectively improves the performances of command following, torsional vibration suppression, and robustness to parameter variation. This is the first time that the ESO has been utilized in torsional vibration control of the main drive system of a rolling mill, and its validity and superiority is verified in comparison with the conventional proportional integral (PI) controller and the state feedback controller based on a reduced-order state observer.

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Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of life. The peripheral nervous system has an inherent capability to regenerate axons. However, peripheral nerve regeneration following injury is generally slow and incomplete that results in poor functional outcomes such as muscle atrophy. Although conventional surgical procedures for peripheral nerve injuries present many benefits, there are still several limitations including scarring, difficult accessibility to donor nerve, neuroma formation and a need to sacrifice the autologous nerve. For many years, other therapeutic approaches for peripheral nerve injuries have been explored, the most notable being the replacement of Schwann cells, the glial cells responsible for clearing out debris from the site of injury. Introducing cultured Schwann cells to the injured sites showed great benefits in promoting axonal regeneration and functional recovery. However, there are limited sources of Schwann cells for extraction and difficulties in culturing Schwann cells in vitro . Therefore, novel therapeutic avenues that offer maximum benefits for the treatment of peripheral nerve injuries should be investigated. This review focused on strategies using mesenchymal stem cells to promote peripheral nerve regeneration including exosomes of mesenchymal stem cells, nerve engineering using the nerve guidance conduits containing mesenchymal stem cells, and genetically engineered mesenchymal stem cells. We present the current progress of mesenchymal stem cell treatment of peripheral nerve injuries.