Aim: Transcriptional regulation is actively involved in the onset and progression of various diseases. This study used the feature-engineering approach model-based quantitative transcription regulation to quantitatively measure the correlation between mRNA and transcription factors in a reference dataset of chronic lymphocytic leukemia (CLL) transcriptomes. Methods: A comprehensive investigation of transcriptional regulation changes in CLL was conducted using 973 samples in six independent datasets. Results & conclusion: Seven mRNAs were detected to have significantly differential model-based quantitative transcription regulation values but no differential expression between CLL patients and controls. We called these genes ‘dark biomarkers’ because their original expression levels did not show differential changes in the CLL patients. The overlapping lncRNAs might have contributed their transcripts to the expression miscalculations of these dark biomarkers.

There is a centralization of the core content in the text information of the new crown epidemic notification. This paper proposes a joint learning text information extraction method: TBR-NER (topic-based recognition named entity recognition) based on topic recognition and named entity recognition to predict the labeled risk areas and epidemic trajectory information in text information. Transfer learning and data augmentation are used to solve the problem of data scarcity caused by the initial local outbreak of the epidemic, and mutual understanding is achieved by topic self-labeling without introducing additional labeled data. Taking the epidemic cases in Hebei and Jilin provinces as examples, the reliability and effectiveness of the method are verified by five types of topic recognition and 15 types of entity information extraction. The experimental results show that, compared with the four existing NER methods, this method can achieve optimality faster through the mutual learning of each task at the early stage of training. The optimal accuracy in the independent test set can be improved by more than 20%, and the minimum loss value is significantly reduced. This also proves that the joint learning algorithm (TBR-NER) mentioned in this paper performs better in such tasks. The TBR-NER model has specific sociality and applicability and can help in epidemic prediction, prevention, and control.

Emotion recognition is essential for computers to understand human emotions. Traditional EEG emotion recognition methods have significant limitations. To improve the accuracy of EEG emotion recognition, we propose a multiview feature fusion attention convolutional recurrent neural network (multi-aCRNN) model. Multi-aCRNN combines CNN, GRU, and attention mechanisms to fuse features from multiple perspectives deeply. Specifically, multiscale CNN can unite elements in the frequency and spatial domains through the convolution of different scales. The role of the attention mechanism is to weigh the frequency domain and spatial domain information of different periods to find more valuable temporal perspectives. Finally, the implicit feature representation is learned from the time domain through the bidirectional GRU to achieve the profound fusion of features from multiple perspectives in the time domain, frequency domain, and spatial domain. At the same time, for the noise problem, we use label smoothing to reduce the influence of label noise to achieve a better emotion recognition classification effect. Finally, the model is validated on the EEG data of 32 subjects on a public dataset (DEAP) by fivefold cross-validation. Multi-aCRNN achieves an average classification accuracy of 96.43% and 96.30% in arousal and valence classification tasks, respectively. In conclusion, multi-aCRNN can better integrate EEG features from different angles and provide better classification results for emotion recognition.