Bying comparing the correlation between three-dimensional speckle tracking echocardiography (3D-STE) and three-dimensional left ventricular ejection fraction (LVEF), to explore the 3D-STE to evaluate the left ventricle of patients with acute ST-segment elevation myocardial infarction (acute STEMI) after percutaneous coronary intervention (PCI) following routine treatment with Tongxinluo drugs.Methods: Altogether, 60 patients with acute STEMI and 30 healthy adults were selected, and the patients were randomly divided into the routine group and the Tongxinluo group, with 30 people in each group. All patients underwent PCI, and routine echocardiography and 3D-STE assessments were performed for each group 72 h after PCI and 12 months after PCI to obtain the following left ventricular related functional parameters: left ventricular end-diastolic diameter (LVEDD), end-ventricular septal end-diastolic thickness (IVSD), left ventricular posterior wall end-diastolic thickness (LVPWD), left ventricular short axis shortening fraction (LVFS), Simpson's left ventricular ejection fraction (Simpson's LVEF), three-dimensional left ventricular ejection fraction (3D-LVEF), global longitudinal strain (GLS), global circumferential strain (GCS), left ventricular twist angle (LVtw), Torsion (Tor), peak strain dispersion (PSD), and myocardial comprehensive index (MCI). The same parameters were collected in the control group, the results were compared, and the correlation analysis between GCS, GLS, LVtw, Tor, and MCIF, and 3D-LVE was performed.Results: Compared with the control group, the LVFS, LVEF (Simpson), 3D-LVEF, GLS, GCS, LVtw, Tor, and MCI significantly decreased in patients with STEMI after PCI, while the PSD significantly increased (P<0.05).Compared with the values 72 h after PCI, the LVEDD, LVFS, LVEF (Simpson), 3D-LVEF, GLS, GCS, LVtw, Tor, and MCI significantly increased at 12 m after PCI, while PSD significantly decreased (P <0.05). No significant difference was observed between the two groups at 72 h after PCI (P>0.05). At 12 months after PCI, the LVEF, GLS, GCS, LVtw, Tor, and MCI of the Tongxinluo group were higher than those of the routine group.The PSD was significantly lower in the Tongxinluo group (P<0.05). MCI and 3D-LVEF have the strongest correlation and highest consistency, which can best reflect the changes in the left ventricular function in patients with acute STEMI after PCI. Conclusion:3D-STE can be used to evaluate the protective effect of Tongxinluo on the left ventricular function in patients with acute STEMI after PCI.

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Purpose: We aimed to investigate the value of the tissue mitral annular displacement (TMAD) technique in evaluating left ventricular systolic function in patients with acute ST segment elevation myocardial infarction (STEMI) treated by Tongxinluo after percutaneous coronary intervention (PCI). Methods: Sixty patients with acute STEMI who underwent emergency PCI were randomly assigned to either the conventional group or the Tongxinluo group. Conventional echocardiography, two-dimensional speckle tracking imaging (2D-STI) and TMAD were performed 72 hours and 12 months after PCI. The following parameters were obtained: left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), stroke output (SV), left ventricular ejection fraction (LVEF-Simpson), global longitudinal strain of left ventricle (GLS), left ventricular global circumferential strain (GCS), septal displacement (TMAD-sep), lateral displacement (TMAD-lat), midpoint displacement (TMAD-midpt) and the percentage of TMAD to LV length from the midpoint of the mitral annulus to the apex at end-diastolic (TMAD-midpt%). And LVEF was measured by three-dimensional automated cardiac function quantification (3DQA) (LVEF-3DQA). Statistical analysis was used to analyze the differences in the above indicators among the groups and their correlations. Results: 12 months after PCI, compared with the conventional group, LVEDD, LVESD and SV decreased, LVEF-Simpson, LVEF-3DQA, GLS, GCS and TMAD parameters increased in the Tongxinluo group (P < 0.05). Correlation analysis showed that TMAD parameters were positively correlated with GLS and LVEF-3DQA, and TMAD-midpt% had the highest correlation with GLS and LVEF-3DQA (r = 0.829，P < 0.01；r = 0.754，P < 0.01), and TMAD-midpt% had good repeatability and good repeatability. Conclusion: TMAD can be used to evaluate the protective effect of Tongxinluo on left ventricular systolic function in patients with acute STEMI after PCI.