We present the case of a 51-year-old Caucasian woman with a history of stage II invasive ductal carcinoma of the left breast that presented atypical erythematous lesions of three months history after radiation two years before for a breast carcinoma. Biopsy was done to distinguish a benign lesion from the main differential diagnosis, which is angiosarcoma. Distinguishing post-radiation benign from malignant vascular lesions can be challenging because they share overlapping clinical and histopathologic features. Thus, any vascular lesion that occurs in a previously irradiated skin should be excised completely with tumor-free margins and examined histologically. Prolonged follow-ups after radiation should be carried on in order to be aware that a lesion in the beginning, which was benign, could be transformed into post radiation angiosarcoma further on in time. There is some evidence that they represent a precursor to radiationinduced angiosarcoma.