No abstract

Coronary artery disease (CAD) is regarded as the principal cause of cardiovascular diseases and one of the leading causes of mortality. In order to alleviate the risk of CAD, percutaneous coronary intervention (PCI) and stent implantation have recently been applied. In particular, Mg alloy (Mg-alloy) stents (MAS) have been used as clinical routine for the treatment of CAD. However, emerging evidence suggests that this treatment strategy is substantially associated with coronary in-stent restenosis (ISR), which remains the main cause of unintentional and repeat drug-eluting stent (DES) interventions in the United States. In this regard, understanding of MAS as friend or foe of ISR treatment is needed to establish the exact mechanism underlying this condition. This mini review therefore aimed to provide an integrated view on the existing findings of the relationship between MAS and ISR. The understanding of MAS as either a friend or foe is crucial for the management of ISR, which is reported to be very challenging amidst lack of effective therapeutic options.

In the past decade, a number of cancer types have been reported to be associated with NCKAP1 encoded as a component of the WASF regulatory complex (WRC) and a poor prognosis. A study of the role of NCKAP1 across various types of tumors was conducted using data from The Cancer Genome Atlas (TCGA). There was an alteration in NCKAP1 expression in most tumor types when compared to corresponding non-tumor tissues. Survival analysis revealed that NCKAP1 overexpression was associated with poor OS and DFS only in kidney renal clear cell carcinoma (KIRC), and upregulated NCKAP1 expression was also significantly associated with the advanced cancer stage suggesting malignant progression in KIRC based on TCGA datasets using GEPIA2; Meanwhile, IHC staining showed NCKAP1 levels of KIRC tissues were significantly lower than normal tissues from HPA database. Following that, NCKAP1 alteration was associated with poor prognosis in cervical squamous cell carcinoma (CSCC) and lung adenocarcinoma (LUAD) patients in terms of PFS analyzed by cBioPortal. As a result, a positive correlation was observed between NCKAP1 expression and cancer-associated fibroblast infiltration in ACC, BRCA, CESC, LGG, and STAD. According to Gene Ontology analysis, NCKAP1 encodes a gene that regulates the actin cytoskeleton function. It was demonstrated from the protein interaction network that NCKAP1 interacts physically with CYFIP1, ABI2, WASF2 and BRK1, which have been well-characterized as actin cytoskeleton cycle regulators and cell disulfidptosis. There was a significant correlation between NCKAP1 expression and tumor prognosis in this multi-tumor study.