Background and Aims-Damage to hepatic sinusoidal endothelial cells (SEC) initiates sinusoidal obstruction syndrome (SOS), which is most commonly a consequence of myeloablative chemo-irradiation or ingestion of pyrrolizidine alkaloids such as monocrotaline (Mct). This study examines whether SEC are of bone marrow origin, whether bone marrow repair can be a determinant of severity of liver injury and whether treatment with progenitor cells is beneficial.

Background: The COVID-19 pandemic has drastically changed healthcare systems and training around the world. The Training Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) sought to understand how COVID-19 has affected pediatric gastroenterology fellowship training. Methods: A 21 question survey was distributed to all 77 pediatric gastroenterology fellowship program directors (PDs) in the NASPGHAN program director database via email on April 7.