The experimental animal study was undertaken to investigate the preventive role ginger juice against hyperglycemia in alloxan induced diabetic rats.Male wistar rats,(130-150)gm wt fed on standard diet and water ad libitum, were divided into 3 groups(n=6) in each group: Group-L non-diabetic control group, Group-II, diabetic control & Group-III, normal rats pretreated with ginger before they were made diabetics. Diabetes was induced by inj. alloxan 150mg/kg body wt.,tp (Group-IL on 2nd day & Group-Ill, on the 9th day).Rats having blood glucose level of more than 7mmol/L on day 5(72 hours after alloxan inj) were considered diabetic & selected for experiment. Rats of Group-Ill received Zingiber officinale (ginger juice) (4m1/kg.body,wt orally) for 7 days (day 2-day8) through Pyles tube before alloxan induction & 3days after the induction. On day 12, animals were sacrificed under light ether anaesthesia, blood was collected by cardiac puncture for blood glucose estimation. Pretreatment with Zingiber officinale (ginger) juice significantly (p<0.01) reduced alloxan induced hyperglycemia.Zingiber officinale (ginger) is one of the most widely used spices and is reputed to have medicinal properties against diabetes mellitus. This study suggests that pretreatment with Zingiber officinale(ginger) prevents the development of hyperglycemia in alloxan induced diabetic rats.

Aims: The present study was performed to investigate the hypolipidaemic effect of natural honey in hyperlipidaemic rats. We also compared the hypolipidaemic effects of natural honey with a standard known hypolipidacmic agent, atorvastatin.Methods: At first the rats (n=42), were randomly divided into six groups. Each group composed of seven rats. Group A control group received normal diet, distilled water for 10 days. Group B hyperlipidemic group received normal diet olive oil (1.5inl) with cholesterol daily for 10 days. Group C received normal diet, distilled water. D, E & F. On the 11th day of experiment the final body weight was measured & blood was collected by cardiac puncture for the study of lipid profile.Result: Only cholesterol fed Group B and C rats gained body weights. Natural honey and atorvastatin treated group of rats. Group D, E, F lost body weights. These changes between the initial and final body weight were statistically significant (p<0.05). Regarding the lipid levels, it was observed that (a) there as statistically significant rise of serum TCI., LDL & TG levels in group B compared to that of group A (p <0.001 in each parameter), b the serum TCL is significantly decreased in group B (p<0.05), and group F (p<0.01) in the comparison to groups; the value also decreased in group D but the decrease was slightly significant (C) the serum LDL level significantly reduced in group D, E & F compared to group C; but the maximum effect comparison to group C; the value also decreased in group D but the decreased was slightly significant. (C) the serum LDL level significantly reduced in group D, E & F compared to group C, but maximum effect was observed in group E & F (p <0.001). (d) No significant change of serum HDL was observed in Group D but slightly significantly increased in group E and group F (p <0.05) compared to group C. (e) The serum TG level reduced significantly (p <0.001) in group D. E and F compared to group C. Thus study showed natural honey reduced TCL, LDL & TG and slightly increase HDL and atorvastatin reduce TCL, LDL & TG. But atorvastatin have some side effect on the other hand natural honey have no side effect.Conclusion: The result and observation of the present study provide a rationale for use of natural honey in the development of a new herbal medicine much needed for the reduction of serum lipid levels (TCL, TO, LDL). Atorvastatin also lower TCL, LDL & TO. Thus it could he useful in hyperlipidaemic conditions. But before establishing natural honey as a therapeutically effective hypolipideamic agent, further studies should be carried out to determine the active principles responsible for hypolipidaemic effect and its cellular mechanism of action.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 94-102