Nursing is a profession that focuses on caring for patients individually, family, or community so that the nurses must be able to prevent, maintain, or restore optimal health and quality of life. Rapid and unpredictable health services placed nurses to occupational-related diseases especially musculoskeletal pain, stress, and obesity condition which can increase the risk of cardiovascular diseases. The aim of the systematic review is to examine the literature on the effective interventions to decrease the occupational-related diseases in nurses. This systematic review was carried out by summarizing the preferred reporting items for literature from January 2014 to June 2019, which produced five articles. The articles were accessed from the internet search engine database; Proquest, EBSCO, and Science Direct. From the five articles reviewed, it was found that three interventions to reduce the occupationalrelated diseases: physical exercise at work, stress management, nutrition and exercise programs in Health education. In conclusion, this review show that single and combination interventions do indeed decrease stress, musculoskeletal pain, and risk of cardiovascular diseases in nurses. However, there is a need for stronger methodological studies to define the most effective and sustainable interventions for each occupationalrelated disease.