Objective: To determine how well machine learning algorithms can classify mild cognitive impairment (MCI) subtypes and Alzheimer’s disease (AD) using features obtained from the digital Clock Drawing Test (dCDT). Methods: dCDT protocols were administered to 163 patients diagnosed with AD(n = 59), amnestic MCI (aMCI; n = 26), combined mixed/dysexecutive MCI (mixed/dys MCI; n = 43), and patients without MCI (non-MCI; n = 35) using standard clock drawing command and copy procedures, that is, draw the face of the clock, put in all of the numbers, and set the hands for “10 after 11.” A digital pen and custom software recorded patient’s drawings. Three hundred and fifty features were evaluated for maximum information/minimum redundancy. The best subset of features was used to train classification models to determine diagnostic accuracy. Results: Neural network employing information theoretic feature selection approaches achieved the best 2-group classification results with 10-fold cross validation accuracies at or above 83%, that is, AD versus non-MCI = 91.42%; AD versus aMCI = 91.49%; AD versus mixed/dys MCI = 84.05%; aMCI versus mixed/dys MCI = 84.11%; aMCI versus non-MCI = 83.44%; and mixed/dys MCI versus non-MCI = 85.42%. A follow-up two-group non-MCI versus all MCI patients analysis yielded comparable results (83.69%). Two-group classification analyses were achieved with 25–125 dCDT features depending on group classification. Three- and four-group analyses yielded lower but still promising levels of classification accuracy. Conclusion: Early identification of emergent neurodegenerative illness is criterial for better disease management. Applying machine learning to standard neuropsychological tests promises to be an effective first line screening method for classification of non-MCI and MCI subtypes.

Malicious software is constantly being developed and improved, so detection and classification of malicious applications is an ever-evolving problem. Since traditional malware detection techniques fail to detect new or unknown malware, machine learning algorithms have been used to overcome this disadvantage. We present a Convolutional Neural Network (CNN) for malware type classification based on the Windows system API (Application Program Interface) calls. This research uses a database of 5385 instances of API call streams labeled with eight types of malware of the source malicious application. We use a 1-Dimensional CNN by mapping API call streams as categorical and term frequency-inverse document frequency (TF-IDF) vectors respectively. We achieved accuracy scores of 98.17% using TF-IDF vector and 95.40% via categorical vector. The proposed 1-D CNN outperformed other traditional classification techniques with overall accuracy score of 91.0%.

Malicious software is constantly being developed and improved, so detection and classification of malwareis an ever-evolving problem. Since traditional malware detection techniques fail to detect new/unknown malware, machine learning algorithms have been used to overcome this disadvantage. We present a Convolutional Neural Network (CNN) for malware type classification based on the API (Application Program Interface) calls. This research uses a database of 7107 instances of API call streams and 8 different malware types:Adware, Backdoor, Downloader, Dropper, Spyware, Trojan, Virus,Worm. We used a 1-Dimensional CNN by mapping API calls as categorical and term frequency-inverse document frequency (TF-IDF) vectors and compared the results to other classification techniques.The proposed 1-D CNN outperformed other classification techniques with 91% overall accuracy for both categorical and TFIDF vectors.