Several uremic toxins have been identified and related to higher rates of morbidity and mortality in dialysis patients. Bisphenol A (BPA) accumulates in patients with chronic kidney disease. The aim of this study is to demonstrate the usefulness of online hemodiafiltration (OL-HDF) in reducing BPA levels. Thirty stable hemodialysis patients were selected to participate in this paired study. During three periods of 3 weeks each, patients were switched from high-flux hemodialysis (HF-HD) to OL-HDF, and back to HF-HD. BPA levels were measured in the last session of each period (pre- and post-dialysis) using ELISA and HPLC. Twenty-two patients (mean age 73 ± 14 years; 86.4% males) were included. Measurements of BPA levels by HPLC and ELISA assays showed a weak but significant correlation (r = 0.218, P = 0.012). BPA levels decreased in the OL-HDF period of hemodialysis, in contrast to the HF-HD period when they remained stable (P = 0.002). In conclusion, OL-HDF reduced BPA levels in dialysis patients.

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Introduction and Aims: Several uremic toxins have been identified and related to higher rates of morbi-mortality in dialysis patients. Bisphenol A (BPA) accumulates in chronic kidney disease (especially in dialysis) due to insufficient renal excretion. The aim of this study is to demonstrate the usefulness of online hemodiafiltration (OLHDF) in reducing BPA levels. Methods: Thirty hemodialysis stable patients were selected to participate in this paired study. During three periods of three weeks each, patients were switched from high-flux hemodialysis (HFHD) to OLHDF and again to HFHD. BPA levels were measured in the last session of each period ( pre and postdialysis) using ELISA and HPLC. Reduction rates of BPA were measured in each period. Results: Twenty-two patients (mean age 73±14 years; 86.4% males) were included in the study. Measurement of BPA levels by HPLC and ELISA assays showed a weak but significant correlation (r=0.218, p=0.012). BPA levels decreased during the OLHDF