In children with CMV abdominal pain, eyelid swelling, skin rash, fatigue and thrombocytopenia were more common. In children with EBV values of transaminases declined significantly faster.

Background/Aim. COVID 19 is a predominantly respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to determine whether there are significant variables which could predict severe clinical picture and fatal outcome in COVID 19 patients. Methods. The research involved 632 patients who were treated at the University Medical Center Kragujevac at the Clinic for Infectious Diseases, in the period from June 2020 to February 2021. All patients were divided into two groups according to the need for oxygen therapy (Sat 02 < 94. Results. Our results showed that high BMI was singled out as a risk factor for the development of a severe clinical picture [BMI [ORadjusted = 1.263; 95% CI = 1.117 - 1.427; p < 0.001]]. Prothrombin time (ORadjusted = 1.170; 95% CI = 1.004 - 1.364; p = 0.045), as well as low albumin values (ORadjusted = 0.878; 95% CI = 0.804 - 0.958; p = 0,003) had a predictive significance for the development of severe clinical picture. Factors that were of predictive importance in patients with fatal outcome were CRP (ORadjusted = 1.010; 95% CI = 1.001 - 1.019; p = 0.031), LDH (ORadjusted = 1.004; 95% CI = 1.001 - 1.006; p = 0.002). X-ray of the lungs (ORadjusted = 1.394; 95% CI = 1.170 - 1.661; p < 0.001). Conclusion. Research has shown that routine, clinical-laboratory parameters can be important in the early detection of patients with a potentially severe clinical picture and fatal outcome. In patients with a mild clinical picture, CRP, LDH, ferritin, and serum albumin levels may indicate timely disease progression. Monitoring of parameters of essential importance for the timely clinical assessment of patients with COVID 19, and thus the timely application of adequate therapeutic protocols in the treatment of these patients.