In recent years, concern has grown over widespread environmental contamination of per- and polyfluoroalkyl substances (PFAS) in the environment and especially in drinking water. These manmade chemicals were first synthesized in the mid-20th century and contain thousands of individual species, some of which are still used today. A wide variety of industries use or have historically used PFAS in their products and processes. PFAS chemicals are recalcitrant by design and thus do not break down in the environment. Federal and state agencies have begun testing of drinking water and other media for PFAS in order to understand the extent of contamination and determine any necessary regulatory actions. Testing is expensive, however, and it would be beneficial to be able to prioritize wells for testing based on their likely vulnerability. This study presents a methodology for identifying locations of industrial sites likely to use PFAS, and uses Michigan’s robust well testing data alongside industry and environmental factors to identify any spatial relationships that can be used to help prioritize testing of wells.