Protein-protein docking is a useful tool for modeling the structures of protein complexes that have yet to be experimentally determined. Understanding the structures of protein complexes is a key component for formulating hypotheses in biophysics regarding the functional mechanisms of complexes. Protein-protein docking is an established technique for cases where the structures of the subunits have been determined. While the number of known structures deposited in the Protein Data Bank is increasing, there are still many cases where the structures of individual proteins that users want to dock are not determined yet. Here, we have integrated the AttentiveDist method for protein structure prediction into our LZerD webserver for protein-protein docking, which enables users to simply submit protein sequences and obtain full-complex atomic models, without having to supply any structure themselves. We have further extended the LZerD docking interface with a symmetrical homodimer mode. The LZerD server is available at https://lzerd.kiharalab.org/.
Deep learning continues to push state-of-the-art performance for the semantic segmentation of color (i.e., RGB) imagery; however, the lack of annotated data for many remote sensing sensors (i.e. hyperspectral imagery (HSI)) prevents researchers from taking advantage of this recent success. Since generating sensor specific datasets is time intensive and cost prohibitive, remote sensing researchers have embraced deep unsupervised feature extraction. Although these methods have pushed state-of-the-art performance on current HSI benchmarks, many of these tools are not readily accessible to many researchers. In this letter, we introduce a software pipeline, which we call EarthMapper, for the semantic segmentation of non-RGB remote sensing imagery. It includes self-taught spatial-spectral feature extraction, various standard and deep learning classifiers, and undirected graphical models for post-processing. We evaluated EarthMapper on the Indian Pines and Pavia University datasets and have released this code for public use.
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