No abstract

1Sustained attention is supported by circuits in the frontoparietal attention network. In human 2 and primate studies, the right posterior parietal cortex (PPC) shows dominance for sustained attention, 3 and phase-amplitude coupling (PAC) throughout the frontoparietal network correlates with 4 performance on attention tasks. Here we evaluate oscillatory dynamics of bilateral PPC in mice during 5 the 5-Choice Serial Reaction Time Task (5-CSRTT). Right PPC theta-gamma PAC (TG-PAC) and gamma 6 power were independently elevated to a greater degree than the left PPC during the period prior to a 7 correct response and were significantly correlated with accuracy in both simple and difficult tasks. 8Greater task difficulty was also associated with greater hemispheric asymmetry in TG-PAC, favoring the 9 right PPC. These findings highlight the engagement of PPC with sustained attention in mice, reflected by 10 increases in TG-PAC and gamma power, with maximal expression in the right hemisphere. 11 12