Chronic ischemic enteritis can cause intestinal strictures, but extensive resection of the small intestine may leave patients with short bowel syndrome. Thus, the importance of preserving diseased small bowel is now recognized. We report a case of successful side-to-side isoperistaltic strictureplasty (SSIS), performed to prevent short bowel syndrome, in a patient with ischemic enteritis caused by strangulated intestinal obstruction. SSIS is useful for preserving the intestinal absorptive function in patients with a long narrowed bowel loop caused by ischemic change. To our knowledge, this is the first report of the successful treatment of a long stricture resulting from ischemic enteritis, achieved by performing SSIS.
Background
Leukoencephalopathy is identified during the administration of anticancer drugs. Symptoms vary from neurological symptoms to psychiatric symptoms depending on the site of damage. There have been no previous reports of suicide attempts due to drug‐induced leukoencephalopathy.
Case Presentation
The patient was diagnosed with diffuse large B‐cell lymphoma (DLBCL) infiltrating the pharyngeal lesion. Rituximab + methotrexate + oncovin + procarbazine (R‐MPV) therapy, a methotrexate‐containing chemotherapy, was initiated. At the end of the fifth course, the patient attempted suicide by hanging with an appliance cord, which was associated with delusion. A head MRI scan showed no evidence of lymphoma recurrence, but white matter lesions around the ventricles showed progression.
Conclusion
We report the case of a patient in whom drug‐induced leukoencephalopathy related to methotrexate led to a suicide attempt. In addition to monitoring brain tumors, daily monitoring of psychiatric and neurological symptoms is important for patients with methotrexate‐induced encephalopathy.
Psychiatric disorders are highly integrated with thyroid disorders; T3 is closely related to depression and anxiety because of its ability to regulate serotonin and noradrenaline. 1 It is also known that psychiatric symptoms often persist after thyroid function is normalized by treatment. 1 In addition, previous studies have shown that bipolar disorder is closely related to thyroid dysfunction. Psychiatric medications can affect thyroid function to a greater or lesser extent, and thyroid hormone (TH) levels can also affect the effectiveness of medications, 2 while thyroid autoimmunity has been suggested to be an independent risk factor for mood disorders. 3 Thyroid hormone resistance (RTH) is a clinical syndrome defined by decreased sensitivity to TH, commonly caused by mutations in the thyroid hormone receptor beta (RTHβ) gene, and referred to as RTH beta or Refetoff syndrome. 4 The exact incidence of RTHβ is unknown because RTHβ is rarely detected by routine thyroidstimulating hormone (TSH)-based newborn screening programs, but
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