Cancer cells often develop drug resistance. In cisplatin-resistant HeLa cisR cells, fibroblast growth factor 13 (FGF13/FHF2) gene and protein expression was strongly upregulated, and intracellular platinum concentrations were kept low. When the FGF13 expression was suppressed, both the cells' resistance to platinum drugs and their ability to keep intracellular platinum low were abolished. Overexpression of FGF13 in parent cells led to greater resistance to cisplatin and reductions in the intracellular platinum concentration. These cisplatin-resistant cells also showed increased resistance to copper. In preoperative cervical cancer biopsy samples from poor prognoses patients after cisplatin chemoradiotherapy, FGF13-positive cells were detected more abundantly than in the biopsy samples from patients with good prognoses. These results suggest that FGF13 plays a pivotal role in mediating resistance to platinum drugs, possibly via a mechanism shared by platinum and copper. Our results point to FGF13 as a novel target and useful prognostic guide for cancer therapy.

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A graded-index plastic optical fiber (GI POF) has been proposed as the transmission medium to realize high-speed information transmission. We have succeeded in fabricating a GI POF by the dopant diffusion coextrusion process, a method that allows continuous fabrication of GI POF. Although it has been indicated that the refractive index distribution of GI POF fabricated by this process is formed by Fick diffusion with the diffusion coefficient dependent on dopant concentration, the method to control it remains unknown. The purposes of this study are to establish the technology of stable fabricating of GI POF by the coextrusion process and to analyze the bandwidth.