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Seeds of Monodora myristica was investigated for its antimicrobial, nutritional and phytochemical properties. Results of the study, shows that the aqueous and ethanolic extracts of the seeds, were active against both gram negative and gram positive organisms used. Important bioactive constituents found to be present in the extracts were alkaloids, anthraquinones, cardiac glycosides, flavonoids, saponins, and phenolic compounds. Yield extracts of the powdered seeds, was for water 7.94% and ethanol 12.5%, indicating that ethanol was the better of the two solvents used. Results of the antibacterial activity of the extracts reveal that the ethanolic extracts at different concentrations were more active against the test organisms namely Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli and Salmonella typhi than the aqueous extracts. The minimum inhibitory concentration (MIC) values for the aqueous extract ranged between 2.5 and 3.0 mg/ml while that for ethanolic extract was between 2.5 and 3.5 mg/ml. The minimum bacterial concentration (MBC) values for aqueous extract ranged between 3.0 and 3.5 mg/ml while that for ethanolic extract ranged between 3.5 and 4.0 mg/ml. Nutritionally result from the study justifies the use of the seed as both a spice and food component by locals. The seed was particularly found to be very rich in potassium and magnesium. There is therefore the need for further studies on the active components of the seeds of Monodora myristica so as to maximize its medicinal and nutritional potential.

Water, fecal and swab samples of poultry walls and cages collected from various poultry farms located in five towns and villages in Ovia North east local government area of Edo State, Nigeria, were screened for the presence of Salmonella spp and antibiotic resistance pattern of the isolates. The prevalence rates recorded shows that Salmonella was isolated from all the sources investigated with varying rates which ranged from 27% for poultry cages to 80% recorded for fecal samples. Overall prevalence rates based on location ranged from 48% to 76%. Result of the resistance pattern of the Salmonella isolates from the various farms reveal that 62% of total 304 isolates tested were resistant to one or more of the antibiotics used with no significant difference in resistance pattern between the locations. Resistance to ampicillin appears to be the most common and was the highest (43%), followed by trimethoprim-sulphamethozazole (39%) and streptomycin (29%), with cephalexin (9%) and gentamycin (10%) recording the least resistance. Worrisome however is the fact the fluoroquinolones which are comparatively new, expensive and could be drug of choice should there be an outbreak, showed some significant degree of resistance (17%). The findings from this study present a potential health problem and are suggestive of the extent of misuse of drugs in medical and veterinary practice in Nigeria.

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The aim of the study is to determine the frequency of urinary tract infection during pregnancy, the susceptibility profile of isolates and the trimester of peak infection. The study which was