Summary
White tea derived from the Camellia sinensis (L.) plant has anticancer effects. Its main catechin decreases the gene expression of Vegf in tumours. However, VEGF is also the angiogenic factor of the reproductive organs. In this study, Wistar rats were divided into the following groups (n = 30): the control group (CT), which received water, and the white tea intake group (WT), for 3 months. At the end of every month, the corpora lutea (CL) of ten rats were removed to evaluate the gene expression of Vegf and its receptors (Flt‐1 and Kdr). White tea increased the relative mRNA abundance of Vegf (CT = 0.95 ± 0.06 and WT = 2.13 ± 0.19), Kdr (CT = 0.88 ± 0.06 and WT = 1.94 ± 0.32) and Flt‐1 (CT = 0.94 ± 0.06 and WT = 2.11 ± 0.22) in CL (P < 0.05). White tea increased angiogenic‐related genes in rat CL but did not alter the number of rat CL.
RESUMOO chá branco é uma bebida saudável, porém esse chá pode interferir em vários fatores de crescimento envolvidos no metabolismo. Portanto, este trabalho teve como objetivo verificar o efeito do consumo prolongado de chá branco nos parâmetros hematológicos de ratas Wistar. Foram utilizados dois grupos de ratas: controle (n=30) que recebeu água e o grupo que recebeu apenas chá branco para beber (n=30). O experimento teve duração de 3 meses, ao final de cada mês, 10 ratas de cada grupo eram eutanasiadas e o sangue dos animais colhido para hemograma e bioquímica sérica. A análise estatística foi a ANOVA seguida do teste de Tukey e Teste T, foram consideradas diferenças estatísticas quando P<0,05. Não houve diferença estatística entre os grupos na contagem de células sanguíneas. Conclui-se que o chá branco não interfere nos parâmetros hematológicos de ratas Wistar.
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