No abstract

No abstract

No abstract

Non-alcoholic fatty liver disease is an important cause of chronic liver damage in many countries and is growing rapidly in both adults and children due to obesity and diabetes type 2. Aim — investigate the effectiveness of complex treatment of patients for the course of NASH using S-adenosylmethionin on the background of basic therapy. The study included 25 patients with non-alcoholic steatohepatitis against type 2 diabetes, age on average (58.69±1.25) years. The control group comprised 15 healthy individuals. In order to identify the diagnosis, data from clinical and laboratory, biochemical and instrumental studies were fully integrated into account. Statistical processing of the results was carried out using Statistica 6.1. In the group of patients with NASH before treatment, the stage I of hepatosis was observed in 15% of cases, the second — in 50%, the third in 35%. Lipid blood spectrum revealed high levels of low and very low density lipoprotein and low levels of high density lipoprotein. High levels of triglycerides among men and high thyroid test among women were determined. The results of the complex (with the inclusion of S-adenosylmethionine) treatment for patients with NASH showed a significant improvement in the subjective state of patients: reduced complaints of discomfort in the right hypochondrium, general weakness, nausea and dizziness. In the ultrasound study in the group of NASH, the redistribution of the number of patients in the side with the reduction of heavier stages of hepatosis was observed: the number of patients with stage I hepatosis was determined in 52.9% of cases (an increase of 3.5 times), stage II — in 24.9% (reduction in 2 times), the third stage — in 22,2% (reduction by 1,5 times). Among all patients, the cytolysis, mesenchymal-inflammatory syndrome, cytology, hemograms improved, and lipid and metabolic parameters were stabilized, confirming the positive membranotropic effect of S-adenosylmethionin on the membrane structures of hepatocytes and indicating anti-inflammatory, hepatoprotective and regenerative effects of the drug in the treatment of patients with steatohepatitis combined diabetes mellitus type 2.

The aim of the study was to identify certain health features among healthy people that can serve as a risk factor and lead to the further development of metabolic syndrome. Materials and methods: A total of 79 men, completely health, were interviewed during 2019 at the Center for Health and Longevity Technology (Kyiv) to assess their health and further correction recommendations for identified abnormalities and available changes. The mean age of men was (37.18 ± 0.89) years. Non-invasive methods were used in the study: determination of anthropometric parameters – height, body weight, waist circumference, abdomen, index of ratio of waist-to-waist circumference, body mass index, body shape index. The constituent compositions of the body were performed with an InBody 220 apparatus with impedance analysis. The metabolic profile was evaluated using FITMATE, a portable metabological device. The cardiovascular profile was determined in the CARDIOLAB + HRV system. The obtained digital data were processed by the method of variational statistics using Microsoft Excel 7.0. Results: It was found that in 44 (54.4%) of the surveyed men, the waist circumference exceeded 94 cm. The largest number of such persons was found among men aged 31-40 years – (29.11% of the surveyed in this group) and persons aged 41-50 years – 21.52%. Fat distribution (waist circumference / hip circumference) averaged (0.83 ± 0.02). The difference in the body shape index between the group of young persons and groups of older men was established. The predisposition to metabolic disorders is established in 49,37% of cases. Determination of metabolic profile revealed a deviation toward an increase in actual metabolism in 15 people and 15 – in the direction of reducing it. Conclusions: Thus, the results of a thorough examination of healthy men showed that they may have health changes that characterize the early signs of disease risk, and their presence can be detected by simple non-invasive research methods. The doctor’s task is to assign an in-depth study of the risk factors for the development of a particularly common in our time prevalence of a complex multicomponent metabolic syndrome, which includes the symptoms of the defeat of many body systems, in particular, the endocrine, cardiovascular, urinary and other in order to preserve human health and to recognize it as early as possible, prevent it and avoid complications.