A single transcranial electrostimulation of rats results, as does acute stress, in a fourfold elevation of plasma corticosterone, whereas after a course of several electrostimulations plasma corticosterone is not elevated and a threefold rise in plasma [~-endorphin is recorded. Rats that undergoing a course of transcmmal electrostimulations and then subjected to an immobilization stress do not show any rise in plasma corticosterone.

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Adaptation to transauricular electrostimulation decreases the content of epinephrine in the adrenal glands and norepinephrine in the heart, hnmobilization stress has no appreciable effect on the content of catecholamines in the heart and adrenal glands. In animals with myocardial inl~arction, the content of norepinephrine in the hem"~ decreases 2-fold, while the content of epinephrine in the adrenals decreases inconsiderably. Adaptation to transauricular electrostimulation is associated with a rise in met-enkephalin concentration. Preadaptation induces a more pronounced rise of met-enkephalin and promotes normalization of epinephrine hi the adrenals, without changing the content of norepinephrine in the hem~.