Introduction: The SARS-CoV-2 virus introduction and subsequent COVID-19 pandemic have had a profound impact on normal dentistry, particularly periodontal treatment, around the world. This cross-sectional study aimed to evaluate the infection surveillance, emergency treatment, economic setbacks, and stress endured by periodontists of South India during COVID-19. Methods: A cross-sectional study was conducted from March to July 2021 among periodontists in South India. A total of 300 periodontists were chosen through the randomized sampling technique. The data were collected using a self-reported closed-end questionnaire consisting of 38 questions through Google Forms. The information was entered into a database and analyzed using SPSS program version 16.0. Results: A total of 300 people took part in the survey, 277 (92.3%) dentists responded to the survey in its entirety. Periodontists and postgraduates made up 24.18% and 75.9% of those who responded, respectively. For all of the questions asked, there was a statistically significant difference among the responses. The majority of respondents agreed on questions about periodontists' knowledge, practice, mentality, and financial setbacks concerning the COVID-19 epidemic. Conclusion: Most of the periodontists that we surveyed have adequate knowledge about SARS-CoV-2 and have been taking adequate measures in preventing the spread of the disease. This pandemic has a negative impact on the periodontists. This study indicates a high level of depression among a significant number of periodontists. It is important to monitor and address the mental health needs of practitioners during the pandemic. The knowledge, awareness, and attitudes regarding teledentistry were found to be satisfactory among the periodontists.