This study aims to examine the effect of workload and work-family conflict on emotional exhaustion. The population of this research are all the emergency room (ER) nurses of all the private general hospitals in Padang. The sample size is 67 people. The sample was classified by using proportional cluster sampling. The data were collected through a questionnaire using Likert scale. Convergent and discriminant validity are used to test the validity and reliability of the questionnaire. Partial least square (PLS) was chosen as the structural equation model (SEM) to test the hypotheses. The study found that: (1) workload has a positive and significant effect on emotional exhaustion, (2) workload significantly influences on work-family conflict, and (3) work-family conflict has a negative and significant effect on emotional exhaustion.