Background and Aims: The ultrasound-guided infraclavicular brachial plexus block (USG ICBPB) is a popular technique for forearm surgeries distal to the elbow. Our study details the ultrasound (US) characteristics of this block and the structures encountered by the needle in four approaches to the infraclavicular area – lateral infraclavicular (LICF), costoclavicular medial to lateral (CML) and lateral to medial (CLM) and retroclavicular (R) by anatomical dissection. Methods: USG ICBPB was performed in 10 cadavers—5 on the right side and 5 on the left side by each of four approaches and with an 18 gauge Tuohy needle kept in situ , and US characteristics were noted. Anatomical dissection was done and important structures were described in detail. Results: Needle tip and shaft visibility were least with LICF approach and best in R approach. Needle angle correlated with chest and neck circumference in LICF and CML groups. During dissection, in all approaches, neurovascular structures have been observed in the near vicinity of the needle, especially the thoracoacromial artery (TAA) or its branches. In the R approach, the 'blind spot' behind the clavicle is an area where neurovascular structures were present. Conclusion: The R approach gives better visibility of needle shaft beyond the clavicle, but the clavicle acts as a 'blind-spot' for the US beam obliterating important neurovascular structures. The various neurovascular structures the needle traverses or in its immediate vicinity, do not necessarily make the CML, CLM or R approach any better than the LICF approach.

The variations in blood vessels are common and have long received the attention of anatomists and surgeons. The true pelvic cavity usually refers to that part of pelvis, which has its bony walls, the sacrum and lower part of hip bone. This small area is well covered by bones and has important structures namely the pelvic viscera, pelvic floor muscles, vessels and nerves supplying it. The aim of the study was to know the branching pattern of internal iliac artery based on the Adachis classification, along with length and thickness of artery. The internal iliac artery was traced from its origin, course, branching pattern, length and thickness of the trunk of internal iliac artery was measured by using digital vernier calliper from its point of origin to bifurcation into anterior and posterior division. The length of right & left internal iliac artery ranged from 2.4 cm to 5.4 cm with average length of 3.943cm ± 0.859cm, whereas the length of left internal iliac artery ranged from 2.7cm to 4.7cm with average length of 3.610cm ± 0.626cm. Bilateral ligation of internal iliac artery is helpful in controlling postpartum haemorrhage. Applying ligatures on an anomalous blood vessel may lead to alarming haemorrhage. The most ideal point of ligation of internal iliac artery would be distal to its posterior division, since proximal ligation has been associated with buttock claudication and necrosis. Knowledge regarding the internal iliac artery and its branches is helpful in applying ligatures safely during pelvic surgeries.

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Significant levels of constitutive cyclooxygenase-2 (COX-2) are present in the male reproductive organs of rodents, especially in the vas deferens and epididymis. In the epididymis, the sperm storehouse, COX-2 is thought to play a vital role in altering the membrane lipids of sperm. The present study aims at localizing COX-2 in the epididymis and analyzing the effects of the preferential COX-2 inhibitor nimesulide. COX-2 protein activity was nearly equal to that of COX-1 in the cauda epididymis. Immunohistochemical studies showed an intense staining for COX-2 in the cauda epididymis but not in the caput epididymis. Nimesulide administration induced a significant reduction in both COX-2 staining intensity and protein activity, followed by an initial decline in total prostaglandin levels but a reversible increase upon sustained COX-2 suppression. Sperm numbers and vitality showed no significant change, but motility decreased and total and free serum testosterone levels mildly increased.

Antibiotics have played a colossal role in managing numerous infectious diseases since their discovery. But today the reckless emergence of AMR and exploitation of antibiotics are of pronounced alarm. Humankind is drifting into an era of multiple drug resistance and an urgent action is required to halt the advent of post-antibiotic era. It is in this regard that the study is undertaken and performed. The aim of this study is to assess the knowledge, attitude and practice of general public centered on antibiotics usage and its resistance. A descriptive study among 516 subjects following with simple random sample selection was conducted between May and July 2020 and was done using a structured questionnaire. The data was analyzed using ANOVA (SPSS VERSION 21.0). Out of 516 respondents, majority has agreed the use of antibiotics in viral infections. About 2/3rd of the population has answered that antibiotics can be taken in cold and cough. About 80% of the population think there is misuse of antibiotics. Around 89% of respondents consult a physician prior to initiate antimicrobial therapy. Our study reveals that the respondents had moderate knowledge and a basic attitude regarding prudent use of antibiotics. Thereby, creating awareness and educating people is significant in the rational use of antibiotics and to minimize the adversities.