Drug induced liver injury (DILI) is uncommon and severe forms are associated with significant morbidity and mortality. Female sex hormones (estrogens and progestogens) related DILI generally occur with estrogen component. Progesterone component related DILI are infrequently reported. Norethisterone is commonly used drug in gynecologic practice to prevent excess per vaginal bleeding. We report 3 cases of Norethisterone related DILI manifesting as significant rise of transaminases. All of these patients took Norethisterone for prolonged periods and improved completely after withdrawal of drug.

Background: Dental implants have become the most common restorative technique for rehabilitation of edentulism. The stability of the crestal bone is believed to be a key factor for maintaining stable soft tissue dimension with direct inuence on aesthetics. The concept of “platform switching” explains the use of a smaller-diameter abutment on a larger-diameter implant collar. This may decrease the risk of bone loss around implants. Aim: To analyze the effect of platform switching on alveolar crestal bone level. Materials and methods: An electronic database search for randomized controlled trials, clinical trials, prospective studies and retrospective studies published in peer-reviewed Journals in English was conducted from the following databases: PubMed, EBSCOhost, EMBASE and Google Scholar. Results: A total 248 articles were identied on electronic database. Eleven studies were included for the qualitative synthesis. Out of the 11 studies, 8 were randomized controlled clinical trials, 1 was a clinical trial, 1 was a prospective study and 1 was a retrospective study. All the included studies suggested that platform switching has signicant effect on alveolar crestal bone level. Conclusion: The platform-switched implants remained stable over the course of 10 years and had an overall survival rate of 97.1%. From the present systematic review, based on the articles that were included in this study, it can be concluded that platform switching technique has signicant reduction in alveolar crestal bone level as compared to platform matched technique.