Background: Copper and zinc in animal diets significantly impact livestock productivity. Zinc is not stored in the body and must be supplemented regularly to maintain optimal immuno-physiological function in animals. Many factors restrict the bioavailability of zinc and its absorption in the intestine. Cu deficiency is common in feed ingredients. Feeding copper levels in the diet is also essential for immune system optimization since copper inhibits the development of metabolic and oxidative stress in dairy cows. Methods: Experimental animals (n=18) were equally divided into three groups with an average body weight 29 kg. T0 was control group with basal diet, T1 group supplemented with copper sulphate (100 mg/goat/day + Basal diet) and T2 group supplemented with zinc oxide (40 mg/goat/day + Basal diet) for 90 days. Blood samples were collected at fortnight intervals and estimated using standard protocols. Result: Total antioxidant capacity (TAC) Superoxide dismutase (SOD) and Catalase were significantly higher in zinc supplemented group followed by copper supplemented group. Thiobarbituric acid reactive substances (TBARS) were significantly lower in the zinc and copper supplemented groups compared to control group. Glucose concentration showed no significant change. Total cholesterol was significantly lower in the copper supplemented group. Total proteins, albumin and triglycerides were significantly higher in the zinc supplemented group than in other groups.