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A B S T R A C T An isotope dilution method, using 'Plabeled pyrophosphate, has been developed for the measurement of inorganic pyrophosphate (PP.) in human plasma. The specificity of the method was better than 90% as assessed by elution patterns during ion-exchange chromatography, by paper chromatography, and by incubation with inorganic pyrophosphatase. The 99% confidence limits for a single estimation of plasma PP. was -+-13%. There were no differences in plasma PPi between men and women, but the values in young people (0-15 yr) were slightly higher than in older people.The mean concentration (±+sE) of PP1 in the plasma of 73 men and women was 3.50 ±0.11 Amoles/liter (0.217 ±0.007 Ag P/ml) and the normal range (99%