Amid the pandemic crisis, patient-reported health behaviours are of high translational value, as essential components of appraising preventative care. Our results demonstrate that COVID-19 vaccine acceptance among patients with psoriasis seems to be driven by heightened risk perception and health awareness, mostly in younger people and highly educated individuals. Nevertheless, our findings should be interpreted with caution, as our study is limited to a single centre.In conclusion, a strong emphasis on the provision of evidence-based information to patients with psoriasis is needed. Factors influencing patients' decision to receive the vaccine and individual features of subpopulations should be considered whenever COVID-19 immunizati/tcgqaon strategies are designed by policymakers and national health systems.