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Background and aims: Hemolytic uremic syndrome (HUS) is the most common IRA child and infant cause. It is rarely described in adults. Aims: Our goal is to clarify the clinico-biological profile, aetiological and evolving entity in children cared for in the pediatric ward of our university hospital over a period of 05ans (2008)(2009)(2010)(2011)(2012)(2013). Methods: This is a retrospective study from the files of patients hospitalized in pediatric wards of our CHU between June 2008 and September 2013. This study focused on children carrying HUS requiring renal replacement therapy by hemodialysis or DP. We took all children aged 0-15 years (107 children). We took into consideration the age sex, mode of presentation, mode of dialysis and evolution. Results: 1o9 on children hospitalized for ARI, 20 HUS cases were collected, representing 18 % of cas.11 children (55%) were male and 9 were female (44 %). Mean age was 22 months + 4mois.Le -mode revelation was anemia with IRA .17 children were purified by peritoneal dialysis, hemodialysis and 2 children. HUS was (+ diarrhea) dans13cas, while the D-HUS was found in 7cas.04 children received infusion PFC. Aucun patient received plasmapheresis. Tho children have received Eculizimab. Normalization of renal function was observed in 10 children (50 % of cases) 3 children (15 %) partially recovered their renal function, there were 6 deaths (30% of cases). Conclusions: Early diagnosis of HUS provides appropriate care. Hemodialysis in children LBW hospital became possible, but support is heavy, DP remains the ERA method best suited to the child. The advent of eculizumab will take better care of atypical HUS.

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