No abstract

Cerebral phaeohyphomycosis is a rare fungal infection of man. There are approximately 53 published cases to date. Xylohypha bantiana has been shown by histology or culture to be the aetiological agent in 28 of these cases. Two cases of cerebral abscess caused by Xylohypha bantiana are presented. One patient was alive eight months after surgery and antifungal drug therapy. His was the first recorded case of cerebral phaeohyphomycosis treated with itraconazole. His course was complicated by adhesive arachnoiditis. The second patient died post-operatively without appropriate treatment.

We determined the antimicrobial susceptibilities of 122 recent clinical isolates of HaemophUus ducreyi to 24 antimicrobial agents. All isolates produced ,-lactamase and were resistant to penicillins. The maEjority of strains were also resistant to tetracycline, doxycycline, and sulfamethoxazole. All isolates were susceptible to macrolides, quinolones, extended-spectrum cephalosporins, spectinomycin, rifampin, and amoxycillin-clavulanate. Reduced susceptibility to minocycline, co-trimoxazole, and kanamycin was noted. Chloramphenicol and thiamphenicol resistance was noted for the first time among southern African strains.