Diabetes mellitus (DM) and abnormal glucose tolerance (IGT) are common in cystic fibrosis (CF). The loss of pancreatic beta-cells due to pancreatic fibrosis is thought to be one of the principal causes of diabetes in CF, but the aetiology of DM remains somewhat puzzling. Genetic factors may contribute to the development of CF related diabetes (CFRD). The purpose of this study was to investigate the role of polymorphisms in six genes on IGT or DM incidence. PCR and dHPLC were used to screen DNA samples for polymorphisms. Using 2-h oral glucose tolerance tests, 163 adult pancreatic insufficient CF patients have been subdivided in 3 groups: 54 NGT (normal glucose tolerance), 33 IGT and 76 CFRD. We found the first evidence for the association between CFRD and UCSNP-19 polymorphism in the CAPN10 gene. The UCSNP-19 genotype distribution differed significantly between NGT, IGT and CFRD groups. The difference reflected an increase in the 22 genotype (3 copies of 32-bp sequence) in IGT and CFRD patients (p=0.05). Odds ratio for the homozygote 22 versus homozygote 11 was 3.4 (p=0.02). All allele and genotype distributions for the other polymorphisms were similar in the three groups. In conclusion, our observations suggest that UCSNP-19 of CAPN10 may be involved in the pathogenesis of diabetes in CF.

UNSTRUCTURED Self-management for type 1 diabetes mellitus patients is a real challenge especially in a time of a spreading pandemic. “Ana wa Soukari” is a newly designed smartphone application for therapeutic education and insulin doses management. Our study evaluated the effectiveness of “Ana wa soukari” on clinical and biological outcomes of type 1 diabetes self-management. Our 3 months’ follow-up results: 62 patients were included in our study. The mean age of our patients was 15 6,41 years. Sex ratio M/F = 1,1. Mean diabetes duration was 4,9 4,3 years and 67,7% of patients had diabetes for less than 5 years. Mean HbA1c levels in Group A (with application) and Group B (without application) dropped from 8,3% 2,3 and 8,2% 2 respectively at baseline to 7,4% 1,5 and 8% 1,8 at three months’ follow-up. Change in hypoglycaemic episodes was – 1,8 2,0 (P < 0,001) for Group A and – 1,2 1,5 (P < 0,001) for Group B. DTSQs was performed in both groups at end point. Scores were significantly higher in group (A) than in group (B) with a mean score of 31,8 3,4 and 28,4 3,8 respectively (P < 0,001). Self-management smartphone apps appear to be effective on glycaemic control and should be considered as an adjuvant intervention to the standard diabetes care.

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