Chronic mucocutaneous candidiasis (CMC) is a rare group of overlapping syndromes that have in common a clinical pattern of persistent and diffuse cutaneous or mucosal candidal infections. It is usually associated with multiple endocrine dysfunctions and autoimmune disorders therefore patient needs a complete systemic evaluation. Patients of CMC are also susceptible to other fungal and viral infections due to impaired cell mediated immunity. We report a case of CMC wherein the cutaneous and mucosal lesions were not associated with any systemic disorder. The patient responded to topical clotrimazole and oral fluconazole.

BACKGROUNDHerpes progenitalis is one of the most common infections in seropositive patients of Human Immunodeficiency Virus (HIV). Studies suggested that the clinical prevalence of genital herpes is higher in HIV-seropositive patients when compared to HIVseronegative patients.

BACKGROUNDThis study was undertaken to determine the epidemiology of leprosy patients attending King George Hospital, between 2016 and 2018. MATERIALS AND METHODSEvery consecutive patient suspected of having leprosy was included in the study. All the patients attending dermatology Out Patient Department and cases referred from other departments were included in the study during the 2 years study period.Total number of patients included in the study-315, Number of males-213, Number of females-102. All patients suspected to have leprosy were confirmed by clinical examination including sensory and motor examination, slit skin smear and biopsy. Confirmed cases were categorized into respective spectrum. The sample included all age groups. Only new cases were included in the study.Statistical analysis used-Percentages and tabular forms are used in this study. RESULTSMost commonly involved are males and between the age group of 25 -45. The overall prevalence of leprosy attending King George Hospital, Visakhapatnam, between the years 2016 and 2018 is 2.5; prevalence among male patients is 1.71; prevalence among female patients is 0.8. The prevalence previously in 2016-2017 as given by the district leprosy prevention office is 0.27. The most common spectrum is of borderline tuberculoid type. CONCLUSIONThe prevalence of leprosy is still continuing to be high and this may be due to the high prevalence in areas in and around Visakhapatnam, Srikakulam and Orissa as most of the patients attending our OPD are from these areas. Endemicity of the disease, poor knowledge of the patients about disease, leads to no treatment or irregular treatment and exposure to close contacts which in turn lead to spread of infection to the susceptible hosts.

BACKGROUND: SLE is a multisystem autoimmune disease with protean manifestations; emphasizing upon the need for a thorough cutaneous and systemic workup. Certain cutaneous features act as forerunners of systemic involvement. AIM: To analyse the association between skin manifestations and systemic involvement and disease activity. METHODS AND MATERIALS: This is an institution based retrospective study conducted over a period of two years with a sample of 30 patients (2 males and 28 females; mean age 22.83 ± 8.53 years) with Cutaneous lupus erythematoses who satisfied atleast 4 out of 11 revised 1982 ARA criteria of SLE in a tertiary care centre. A thorough clinical, investigative and mortality data has been collected from the records. The diagnosis has been confirmed using histopathological and immunological analysis in all the patients. The disease activity and severity have been determined by using SLEDAI-2K score. The statistical evaluation has been carried out by determining the frequency of occurrence of systemic involvement in relation to cutaneous manifestations and p value by Fischer's exact test of significance has been calculated. RESULTS: Cutaneous manifestations like malar rash, photosensitivity, noncicatricial alopecia, oral ulcers and vasculitis are associated with systemic involvement. CONCLUSIONS: Cutaneous manifestations in SLE can be considered as markers of systemic involvement and indicate a prima facie suspicion which can guide in instituting appropriate management.

BACKGROUND Many proved studies link active cigarette smoking to cervical neoplasia, but very less information and evidence is known about the role of passive smoking and its effect on cervix and its epithelium. The main aim and objective of our study is to examine household passive smoke exposure and its role in development of cervical neoplasia. MATERIALS AND METHODS Our study included 100 women visiting outpatient STD Clinic, King George Hospital, Visakhapatnam in the months of July and August 2017. Out of 100 randomly selected women 50 women were non-smokers but exposed to passive smoking and another 50 women were non-smokers and not exposed to passive smoking. All of them were subjected to Pap smear testing. Chi-square test and 'p' values have been calculated. Study Design-This is an observational, descriptive, cross-sectional study done at a single point of time by assessing Pap smear tests in various categories of selected women. Study Setting-The study was conducted in hundred women attending the