The purpose of the present study was to investigate the effect of inclusion graded levels of Moringa oleifera leaf powder (MOLP) as a safe feed additive on productive performance, some blood parameters, egg quality traits and egg cholesterol contents of Lohamnn chicken. A total number of 150 hens, aging 20 weeks were randomly allocated in a completely randomized design to 5 dietary treatments, in each three replicates (n=10) and their initial mean body weight ranged from 1501.0 to 1530.0 g (±7.01), where each 2 birds were placed in one cage. The control group was fed a corn-soybean meal based diet and the other experimental groups were fed on control diet supplemented with 0.5%, 1.0%, 1.5% and 2.0% MOLP. The results revealed that laying performance statistically (P≤0.05) improved due to the addition of MOLP as compared to the control group. Furthermore, FCR recorded the best values for groups fed MOLP, which displayed relatively high performance. However, inclusion of MOLP in diets improved both egg shell thickness and yolk color. In addition, egg cholesterol contents significantly (P≤0.05) decreased due to increasing levels of MOLP in diets. Obliviously, health status as judged by measuring some blood constituents, showed decreases (P≤0.05) of lipid profile and Corticosterone concentration, while level of HDL and protein profile significantly (P≤0.05) increased due to the addition of MOLP in the diets. Clearly, it can be recommended that the incorporating of MOLP in Lohmann chickens diets could enhance their productive performance and improve physiological status.