Cyclins are a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases, have been reported in various malignant tumors. Expression of cyclin B1, D1 was investigated with immunohistochemical method in 69 cases of primary ovarian carcinoma. Five-year survival and degree of differentiation have been found to depend on сyclins D1, В1.
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