Background:The association between Hyperuricemia (HUA) and Contrast Induced-Acute Kidney Injury (CI-AKI) has not been extensively studied. The aim of our study was to evaluate the association between HUA and CI-CKD in patients with acute ST-Elevation Myocardial Infarction (STEMI) undergoing Percutanious Coronary Intervention (PCI). Methods:We prospectively studied 146 patients with acute STEMI undergoing PCI. According to serum uric acid (SUA), patients were divided into 2 groups, normouricemic group (Group 1, n=68) and hyperuricemic group (Group 11, n=78). HUA was defined as a SUA concentration of more than 7.0mg/dL in men and 6.0mg/ dL in women. Medical records of both groups of patients were reviewed for the occurrence of AKI. Multi-variate regression analysis was used to define independent risk predictors of AKI.Results: AKI was found in 11 of 78 (14.1%) in Group I1 of patients and in 2 of 68 (2.94%) in Group 1 of patients (p=0.0436), baseline Serum Creatinine (SCr) and Estimated Glomerular Filtration Rate (eGFR) were comparable between the two groups. There was positive significant correlation between admission SUA and SCr 48h after PCI in the studied patients. According to regression analysis, SUA, age, Left Ventricular Ejection Fraction (LVEF), multi-vessel disease and volume of Contrast Media (CM) were found to be independent risk factors of AKI. After adjusting for age, sex, LVEF, multi-vessel disease, and volume of CM, SUA remained as an independent risk factor for CI-AKI. Conclusion:Elevated uric acid was associated with higher risk for AKI in STEMI patients with normal SCr treated with PCI.