Introduction: Writer's cramp is a specific focal hand dystonia causing abnormal posturing and tremor in the upper limb. The most popular medical intervention, botulinum neurotoxin type A (BoNT-A) therapy, is variably effective for 50-70% of patients. BoNT-A non-responders undergo ineffective treatment and may experience significant side effects. Various assessments have been used to determine response prediction to BoNT-A, but not in the same population of patients.Methods: A comprehensive assessment was employed to measure various symptom aspects. Clinical scales, full upper-limb kinematic measures, self-report, and task performance measures were assessed for nine writer's cramp patients at baseline. Patients received two BoNT-A injections then were classified as responders or non-responders based on a quantified self-report measure. Baseline scores were compared between groups, across all measures, to determine which scores predicted a positive BoNT-A response.Results: Five of nine patients were responders. No kinematic measures were predictably different between groups. Analyses revealed three features that predicted a favorable response and separated the two groups: higher than average cramp severity and cramp frequency, and below average cramp latency.Discussion: Non-kinematic measures appear to be superior in making such predictions. Specifically, measures of cramp severity, frequency, and latency during performance of a specific set of writing and drawing tasks were predictive factors. Since kinematic was not used to determine the injection pattern and the injections were visually guided, it may still be possible to use individual patient kinematics for better outcomes.

The increasing need for sharing workspace and interactive physical tasks between robots and humans has raised concerns regarding safety of such operations. In this regard, controllable clutches have shown great potential for addressing important safety concerns at the hardware level by separating the high-impedance actuator from the end effector by providing the power transfer from electromagnetic source to the human. However, the existing clutches suffer from high power consumption and large-weight, which make them undesirable from the design point of view. In this paper, for the first time, the design and development of a novel, lightweight, and low-power torque-adjustable rotary clutch using electroadhesive materials is presented. The performance of three different pairs of clutch plates is investigated in the context of the smoothness and quality of output torque. The performance degradation issue due to the polarization of the insulator is addressed through the utilization of an alternating current waveform activation signal. Moreover, the effect of the activation frequency on the output torque and power consumption of the clutch is investigated. Finally, a timedependent model for the output torque of the clutch is presented, and the performance of the clutch was evaluated through experiments, including physical human-robot interaction. The proposed clutch offers a torque to power consumption ratio that is six times better than commercial magnetic particle clutches. The proposed clutch presents great potential for developing safe, lightweight, and low-power physical human-robot interaction systems, such as exoskeletons and robotic walkers.