Infliximab is not superior to placebo in preventing clinical recurrence after CD-related resection. However, infliximab does reduce endoscopic recurrence. ClinicalTrials.gov ID NCT01190839.

Two pregnant women with severe status asthmaticus unresponsive to intensive medical treatment are reported. Termination of pregnancies by cesarean section was followed by a dramatic improvement within 24 h. Termination of pregnancy is indicated in life-threatening status asthmaticus

Anaesthesia for cardiac catheterisation in infants and children remains a challenge to the anaesthetist. A wide variety of methods has been advocated' but none of these has proved completely satisfactory, nor is there, as yet, a single well-recognised technique which is accepted in all centres.It is generally agreed that there should be minimal fluctuations in physiological parameters during cardiac catheterisation if false data is not to be obtained from the procedure; alterations in oxygen tension in the inspired air and intermittent positive pressure ventilation should, therefore, be avoided as far as is possible.* The introduction of ketamine has provided an anaesthetic which has proved to have advantages over others currently employed for cardiac catheterisation ; its use as a sole agent for this purpose has been described by several a~t h o r s .~-~ The advantages claimed for ketamine include its ease of administration, the rapidity of induction, the ease in maintaining an unobstructed airway and the minimal respiratory depression. Anaesthesia can be maintained for extended periods without endotracheal intubation and with the patient breathing air rather than unphysiological gas mixtures.Certain characteristic cardiovascular responses to ketamine administration have been observed and reported in both humans and anirnak6 These include an increased cardiac output, hypertension and tachycardia with little or no change in the systemic peripheral re~istance.~ These haemodynamic changes have also been noted by the authors when using ketamine in the diagnostic cardiac catheterisation Iaboratory over the past 4 years.

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