Abstract: Deciding the right classification algorithm to classify and predict the disease is more important in the health care field. The eminence of prediction depends on the accuracy of the dataset and the machine learning method used to classify the dataset. Predicting autism behaviors through laboratory or image tests is very time consuming and expensive. With the advancement of machine learning (ML), autism can be predicted in the early stage. The main objective of the paper is to analyze the three classifiers Naïve Bayes, J48 and IBk (k-NN). An Autism Spectrum Disorder (ASD) diagnosis dataset with 21 attributes is obtained from the UCI machine learning repository. The attributes have experimented with the three classifiers using WEKA tool. 10-fold cross validation is used in all three classifiers. In the analysis, J48 shows the best accuracy compared with the other two classifiers. The architecture diagram is shown to depict the flow of the analysis. The Confusion matrix with other relevant results and figures areshown.