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Over the previous decade, cardiovascular disease fatalities worldwide have risen by around 20 percent, with the majority of deaths happening in poor and middle-income nations (nearly 70 percent of all cardiovascular disease deaths). The purpose of this study was to examine the relationship between local EFT, PCFT, and PCFD with the existence and severity of coronary artery disease. Methods: In an imaging facility, researchers conducted this crosssectional single-center study. Patients who were sent for MSCT coronary angiography had either known or suspected coronary artery disease and were evaluated noninvasively. Results: There was no significant difference in male and female distribution in the non-atherosclerosis group, where men were more abundant, with a P value of 0.45. Regarding the risk factors of the individuals evaluated in our research, Except for those with a family history of atherosclerosis, we found a statistically significant rise in the risk variables high blood pressure, diabetes mellitus, smoking, and hyperlipidemia in the non-atherosclerosis group. There was no statistically significant difference between individuals in terms of coronary artery disease impacted by the procedure. Prognostic imaging biomarker MSCT may help identify coronary artery disease at an early stage as well as estimate risk.