This study was carried out at the teaching and Research farm, Department of Horticulture and Landscape Technology, Akanu Ibiam Federal Polytechnic, Unwana, to investigate the integrated effects of organics (lime, Inoculum) and mineral fertilizers, (single superphosphate and muriate of potash) on the growth, nodulation and yield of soybean. The input omission trial was composed of 16 treatment combinations of phosphorus (75 kg/ha), potassium (88 kg/ha), lime (1500 kg/ha), and inoculum (400g/100kg seed). Each set of 16 treatments were randomized and replicated 3 times. The soybean variety “TGX1951-3F” was planted in 0.5 m by 1 m plots with a seed spacing of 5 cm. Data on number of nodules and nodule viability at 45 days after planting, plant height at 90 days after planting, number and weight of 100 seeds per plot and yield per plot at harvest were collected and analyzed using Analysis of Variance (ANOVA) in R using the package “car” to test the main treatment effects, 2-way, 3-way, and 4-way treatment interactions in the omission trial. Results showed highly significant effects of treatments on the growth, nodulation and yield of soybean. The no input treatment generally had the most appreciable improvement in plant height, nodule viability, weight of 100 seeds and yield. Inoculated seeds had the highest number of nodules and percent nodule viability (5 and 69% respectively). . 2.12ton/ha yield generated by the no input treatment shows the potential for future higher yield especially when climatic and good agronomic strategies are employed.