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Background:Organophosphate (OP) poisoning is an important reason for hospitals and intensive care units admission in the developing countries. OP poisonings are classically treated with atropine and oximes. These methods are sometimes shown to be of limited benefit. Objective: Assessment of the effectiveness of the management with fresh frozen plasma (FFP) in improving the outcome of patients with acute OP poisoning. Patient and Methods: A randomized clinical trial study was conducted upon 70 acute OP poisoning patients that were referred to the Emergency Department, Suez Canal University Hospital, Ismailia, Egypt. These patients were randomly divided into two groups (35 each); Control group: Treated with the traditional management protocol of OP (atropine and oximes). FFP group: Treated with the conventional management protocol of OP plus FFP. Results: No significant difference was found in cholinesterase level on admission between both groups, Serum cholinesterase level in the FFP group significantly increased after an hour of FFP infusion (2.48 iu/ml vs. 10.36 iu/ml p<0.0001). There is a significant difference between both groups regarding the duration of their hospital stay (2.43 ± 0.5 days for FFP group vs. 3.06 ± 1.4 days for control group; p<0.01) and intensive care unit admission (4 patients in FFP group vs. 12 patients in the control group; p<0.04). Conclusion Early management with FFP may be an effective method for the management of acute OP poisoning, as it can improve the clinical outcome through decreasing mortality, duration of hospital stay and the need for ICU admission.

Severe physiological and biochemical abnormalities provide a significant risk of death in the clinic, making sepsis a potentially fatal illness. Sepsis is now defined as "organ dysfunction induced by a dysregulated host response to infection," under the Third International Consensus (Sepsis-3). Our research aimed to determine the best methods for determining whether a critically sick patient with sepsis had reached the end of fluid treatment by comparing the results of lung ultrasonography, central venous pressure, and IVC diameter and collapsibility index. Methods: Fortyfive patients from the intensive care unit at Banha university hospital participated in the cohort research. Results: At admission, this research found that hypovolemia was linked to lower CVP, lower dIVC max and lower dIVCmin, and greater IVC CI, but that there was no significant difference between hypo and euvolemia in LUSS. Over the course of 120 minutes, CVP, dIVC max, dIVC min, LUSS, and IVCCI all rise gradually, whereas IVCCI falls gradually over the first 30 minutes. The AUCs for predicting hypervolemia using IVC CI and LUSS were moderate. The current investigation demonstrated a robust positive link between CVP, LUSS, and dIVCmin/max following fluid consumption over time, and a substantial negative correlation between IVCCI and these same variables. Prediction of hypervolemia for the purpose of discontinuing fluid infusion was thought to be possible with a lower IVC-CI and a greater LUSS. In conclusion, assessing the endpoint of fluid treatment in patients with hypovolemic shock due to sepsis is made more easier and more accurate using lung ultrasound due to its noninvasive nature and high sensitivity and specificity. Prediction of hypervolemia for the purpose of discontinuing fluid resuscitation in septic patients was shown to be best accomplished by a combination of a lower IVC-CI and a higher LUSS. Evaluation of the collapsibility index of the inferior vena cava provides a low-risk, high-sensitivity alternative to monitoring central venous pressure. A low CVP was shown to be an unreliable indicator of fluid responsiveness.

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Although the exact cause of osteoarthritis (OA) is unknown, it is believed to be a collection of related but distinct diseases that can occur due to a variety of biological and mechanical factors, such as metabolic predisposition, genetic or hereditary predisposition, age, and physical factors like obesity. Slowly progressing articular disease, osteoarthritis causes joint pain, stiffness, and a loss of mobility. Anti-inflammatory characteristics of corticosteroids make them popular in pain management. Adrenal corticosteroids are commonly utilised in epidural, joint, peripheral nerve, and soft tissue injections. They are produced in the adrenal cortex. It was the goal of this study to assess the effectiveness of ozone, steroid, and a placebo in patients with osteoarthritis of the knee following radiofrequency ablation of the genicular nerves. It was conducted at the Benha university hospital and comprised 75 patients with osteoarthritis of the knee joint who were randomly assigned to receive either a placebo or an active treatment. No differences were found between the study groups in age, gender, BMI, pain duration, or Kellgren-Lawrence grade, according to the research. The median VAS score revealed a considerable disparity among the three study groups. Results showed it was substantially higher in group I (7 points) than in groups II (six points) and III (4 points) (5). At the beginning of the research, there were no significant differences between the study groups in terms of VAS. In terms of the oxford knee score (OKS), there was no significant difference between the study groups at the beginning. There was no discernible difference in overall patient satisfaction across the trial groups. Patients with osteoarthritis of the knee had their genicular nerves ablate using radiofrequency.