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56% (14/25) of cases treated with alternative regimens (p¼0.16). Mean duration of latency was 2.2 days (AE standard deviation (SD) 2.7) among cases treated with first-line antibiotics, compared to 1.8 days (AE SD 2.2) among cases treated with alternative regimens (p¼0.51). Results were confirmed in multivariate analyses. CONCLUSION: The use of alternative antibiotic regimens for the treatment of PPROM in cases of reported penicillin allergy was not associated with a significant difference in latency. However, due to small sample size, we were unable to evaluate alternative antibiotic regimens individually.