BackgroundThis 4 phase project1 jointly supported by EULAR and ACR has led to draft criteria.2
ObjectivesTo simplify and validate the new criteria in a large international cohort.Methods23 expert centres each contributed up to 100 patients with SLE and with non-SLE diagnoses. Diagnoses were verified by 3 independent reviewers for 1,193 SLE and 1059 non-SLE patients. 500 randomly selected SLE and non-SLE patients formed the derivation cohort and the remainder the validation cohort.ResultsThe criteria were fine-tuned and simplified, using ANA of ≥1:80 as entry criterion and a classification threshold of 10.RenalClass III/IV nephritis10Class II/V nephritis8Proteinuria≥0.5 g/day4
Specific antibodiesAnti-Sm orAnti-dsDNA6Muco-cutaneousACLE6SCLE orDLE4Alopecia or oral ulcers2SerosaAcute pericarditis6Effusion5Musculo-skeletalArthritis6CNSSeizures5Psychosis3Delirium2BloodAutoimmune hemolysis or thrombocytopenia4Leukopenia3ComplementLow C3 and C44Low C3 or C43Anti-phospholipidAnti-Cardiolipin or anti-β2-GPI or lupus anticoagulant2ConstitutionalFever2Sensitivity was close to the SLICC 2012 criteria, specificity maintained at the level of the ACR 1997 criteria. This performance was independently confirmed in the validation cohort.ACR 1997 criteriaSLICC criteriaNew criteria
DerivationSensitivity84.6396.8198.00Specificity95.2090.0096.40ValidationSensitivity82.7696.7096.12Specificity93.3883.6293.38ConclusionsThe new criteria developed with EULAR/ACR support achieved sensitivity close to the SLICC criteria, while maintaining the specificity of the ACR criteria.References[1] Aringer, et al. Ann Rheum Dis2017;76(S2):4.[2] Tedeschi, et al. Ann Rheum Dis2017;76(S2):50.Disclosure of InterestNone declared
The Andean grain, quinoa, Chenopodium quinoa Willd. (Caryophyllales: Amaranthaceae), is gaining increasing attention as a future food and fodder crop in Denmark and other parts of Europe. Prior to 2005, pest problems in the crop were negligible in Denmark, however native insects may become adapted to this new host. Herbivores feeding on the closely related and very common weed in arable crops Chenopodium album L. present a special risk. In 2006 there was a heavy attack of Scrobipalpa atriplicella (Röslerstamm) (Lepidoptera: Gelechiidae) larvae in the maturing inflorescence of C. quinoa. Gelechiidae are the most important pests on C. quinoa in the Andean region. In 2007 another herbivore on C. album, the tortoise beetle Cassida nebulosa L. (Coleoptera: Chrysomelidae), was a serious problem on C. quinoa in southern Jutland. This is the first published record of these two pests on C. quinoa. The future pest status of C. quinoa in northern Europe is discussed.
The original version of this Article contained an error in the spelling of the author Ana Rodríguez-Ramos, which was incorrectly given as Ana Rodríguez Ramos. This has now been corrected in both the PDF and HTML versions of the Article.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.